Biological Theory of DepressionEvidence that depression is related to genetics has been growing recently, as more and more research is being done to examine the role the brain and heredity play in the likelihood an individual will develop depression. For the first time in the early 1980s visible evidence of depression having a biological tie showed up in laboratory tests that examined the brain's functioning in depressives (Lowry, 1984). Studies showed that at least half of the depressives examined had increased levels of activity in the hypothalamic- pituitary-adrenal axis of the brain (Lowry, 1984). Other medical evidence that supports the biological model of depression are the documentation of higher than normal amounts of cortisol discharges in the adrenal glands of depressives, and eccentric brain wave patterns as recorded by electroencephalograms (EEGs) (Lowry, 1984).
Research has also shown depression has a tendency to run in families. Most published research covers bipolar depression, but researchers have concluded there is reason to believe unipolar depression can be inherited and is thus a biological illness (Schwartz & Schwartz, 1993).
In twin studies done examining bipolar depression, researchers have found the likelihood to be 80 percent both twins will develop bipolar depression if at least one has it (Schwartz & Schwartz, 1993). Adoption studies done in research of affective disorders as a whole have shown there is a strong concordance rate of depression (Schwartz & Schwartz, 1993).
Criticisms of the biological model are it ignores environmental factors when looking at the relationship of depression in family studies, and the concordance rate in identical twin studies is not 100 percent. If depression can be inherited, critics argue, then both identical twins should inherit it (Schwartz & Schwartz, 1993). Proponents of the biological model, however, point out it is the predisposition of depression inherited, not the illness itself (Schwartz & Schwartz, 1993). Even identical twins don't experience the same life events.




